Reactions that occurred in urticaria are hypersensitivity reactions, or overreaction to substances that are actually very common. Now, on cholinergic urticaria, this occurs due to stimulation of the autonomic nervous system in the crust. The typical symptoms can be in a form of patches of redness to bump in small pieces that follow the size of skin pores. The cause of the small bump is the change in the ability of blood vessels to hold the liquid inside (permeability) so that the fluid is out and appear as a small bump on the skin. Meanwhile, itching, caused by stimulation of certain body cells in the skin area, such as mast cells, which then rupture and release materials mediators, e.g. histamine, which causes itch.

Principally, cholinergic urticaria occurs when someone is starting to sweat. For example is when he does a lot of activity or other things that trigger sweating, such as emotional factors, stress, certain foods, or hot weather. The abnormalities starting from red spots up to little bumps will subside after the sweat disappears.

Although the process is unclear, urticaria sometimes can be reduced accordingly. It seems like there is a process of adaptation until finally the symptoms do not appear again. The process of adaptation is used as the basis for the implementation of desensitization therapy, i.e. therapy to make someone no longer sensitive to certain ingredients. However, until now the results are still not yet predicted with certainty.
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